Children (Basel). 2026 May 12;13(5):669. doi: 10.3390/children13050669.ABSTRACTBackground: Cardiac channelopathies are rare but potentially life-threatening disorders that may present with syncope or seizure-like episodes in children, often leading to misdiagnosis and delayed recognition. Other arrh
Cells. 2026 May 9;15(10):868. doi: 10.3390/cells15100868.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a genetic myocardial disorder marked by progressive cardiomyocyte loss, fibro-fatty replacement, ventricular arrhythmias, and risk of sudden cardiac death. Traditionally considered a structural an
Int J Cardiol. 2026 Aug 15;457:134538. doi: 10.1016/j.ijcard.2026.134538. Epub 2026 May 3.ABSTRACTBACKGROUND: While moderate-intensity endurance exercise is recommended in patients with and without dilated aorta, little is known about aortic physiology during isometric and resistance exercise.METHOD
J Am Heart Assoc. 2026 May 5;15(9):e047447. doi: 10.1161/JAHA.125.047447. Epub 2026 Apr 28.ABSTRACTBACKGROUND: Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin-2 (PKP2) deficiency only in cardiomyo
Open Heart. 2026 Mar 31;13(1):e003750. doi: 10.1136/openhrt-2025-003750.ABSTRACTBACKGROUND: Truncating variants in the titin gene (TTNtv) are associated with cardiomyopathy, mainly dilated cardiomyopathy (DCM). The clinical presentation and outcomes of arrhythmogenic phenotypes in these patients are
Medicine (Baltimore). 2026 Mar 6;105(10):e47481. doi: 10.1097/MD.0000000000047481.ABSTRACTRATIONALE: Arrhythmogenic left ventricular cardiomyopathy (ALVC) is an arrhythmogenic cardiomyopathy characterized by nonischemic left-ventricular scar, ventricular arrhythmias, and risk of sudden cardiac death
Cureus. 2026 Jan 29;18(1):e102553. doi: 10.7759/cureus.102553. eCollection 2026 Jan.ABSTRACTPediatric ischemic stroke is an uncommon but serious neurological condition with highly variable etiologies. Cerebellar infarctions are particularly rare in children and often present with nonspecific symptom
Circ Arrhythm Electrophysiol. 2026 Feb;19(2):e014265. doi: 10.1161/CIRCEP.125.014265. Epub 2026 Jan 29.ABSTRACTBACKGROUND: The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populat
Zool Res. 2026 Jan 18;47(1):139-154. doi: 10.24272/j.issn.2095-8137.2025.044.ABSTRACTArrhythmogenic cardiomyopathy (ACM) confers elevated risk of ventricular arrhythmias and sudden cardiac death, yet limitations in early lesion sampling and model development continue to hinder mechanistic and transl
BMC Med Imaging. 2026 Jan 28;26(1):102. doi: 10.1186/s12880-026-02172-y.ABSTRACTBACKGROUND: The importance of right atrial (RA) function assessment in arrhythmogenic right ventricular cardiomyopathy (ARVC) is increasingly being recognized. MR-feature tracking (MR-FT) has emerged as a novel approach
Circ Heart Fail. 2026 Apr;19(4):e013801. doi: 10.1161/CIRCHEARTFAILURE.125.013801. Epub 2026 Jan 26.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a fatal genetic heart disease primarily caused by mutations in desmosomal genes, leading to impaired cell-cell adhesion, ventricular arrhythm
PLoS One. 2025 Dec 18;20(12):e0339129. doi: 10.1371/journal.pone.0339129. eCollection 2025.ABSTRACTThe transmembrane protein 43 (TMEM43) S358L mutation is the most common mutation found in patients with ARVC5, a severe subtype of arrhythmogenic right ventricular cardiomyopathy (ARVC). Characterizing
Vet Rec. 2026 Mar-Nov 28;198(7):e287-e292. doi: 10.1002/vetr.6014. Epub 2025 Dec 6.ABSTRACTBACKGROUND: Evidence regarding the diagnostic utility of serum anti-desmoglein-2 (DSG2) autoantibodies for arrhythmogenic right ventricular cardiomyopathy (ARVC) in boxer dogs is conflicting.METHODS: Prospecti
JACC Cardiovasc Imaging. 2026 May;19(5):571-584. doi: 10.1016/j.jcmg.2025.10.019. Epub 2025 Dec 4.ABSTRACTBACKGROUND: Right ventricular outflow tract (RVOT) dilatation is a phenotypic feature of arrhythmogenic right ventricular cardiomyopathy (ARVC). The echocardiographic RVOT diameter is part of th
Turk J Pediatr. 2025 Oct 6;67(5):748-754. doi: 10.24953/turkjpediatr.2025.4906.ABSTRACTBACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal, genetically transmitted cardiomyopathy that can cause unpredictable malignant life-threatening arrhythmias. Arrhythmias that may be he
Biomolecules. 2025 Nov 6;15(11):1565. doi: 10.3390/biom15111565.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a cardiac disorder manifesting through electrical and contractile dysfunction of the ventricles, characterized by fibro-fatty substitution of the myocardium. Cardiac mesenchymal stromal cel
Biomolecules. 2025 Oct 25;15(11):1512. doi: 10.3390/biom15111512.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a genetic cardiac disease characterized by a progressive loss of cardiomyocytes associated with fibrofatty myocardial replacement, resulting in a heightened risk of ventricular arrhythmias
Cell Mol Life Sci. 2025 Nov 14;82(1):400. doi: 10.1007/s00018-025-05942-z.ABSTRACTArrhythmogenic right ventricular cardiomyopathy type 5 (ARVC-5) is a fully penetrant form of ARVC caused by the missense mutation in the gene TMEM43p.S358L. Despite extensive research, the molecular basis underlying th
ESC Heart Fail. 2025 Dec;12(6):4419-4430. doi: 10.1002/ehf2.70013. Epub 2025 Nov 12.ABSTRACTAIMS: Arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease characterized by fibrofatty myocardial replacement and a predisposition to malignant ventricular arrhythmias. The underlying pathomechan
Am J Physiol Heart Circ Physiol. 2025 Dec 1;329(6):H1608-H1620. doi: 10.1152/ajpheart.00416.2025. Epub 2025 Nov 10.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is an inherited heart disease characterized by myocardial inflammation and fibrosis, ventricular dysfunction, and arrhythmias, and is a leadi
Int J Cardiol. 2026 Feb 1;444:133999. doi: 10.1016/j.ijcard.2025.133999. Epub 2025 Nov 5.ABSTRACTBACKGROUND: The classification of left ventricular cardiomyopathies is challenging due to evolving definitions and overlapping phenotypes. The European Task Force Criteria, by incorporating structural, f
Stem Cell Res Ther. 2025 Nov 4;16(1):609. doi: 10.1186/s13287-025-04755-y.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a genetically inherited desmosome heart disease leading to life-threatening arrhythmias and sudden cardiac death. Currently, ACM treatment paradigms are merely symptom
Commun Biol. 2025 Oct 27;8(1):1502. doi: 10.1038/s42003-025-08921-z.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is an inherited heart disease marked by progressive fattyfibro replacement of the ventricular myocardium, life-threatening arrhythmias, and sudden cardiac death. To dissect epicardial cont
JACC Clin Electrophysiol. 2025 Nov;11(11):2532-2547. doi: 10.1016/j.jacep.2025.08.026. Epub 2025 Oct 16.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a heritable cardiac condition, which may lead to fatal arrhythmias, especially during intense exercise. Long-term regular exercise is associated with
