PLoS One. 2025 Dec 18;20(12):e0339129. doi: 10.1371/journal.pone.0339129. eCollection 2025.ABSTRACTThe transmembrane protein 43 (TMEM43) S358L mutation is the most common mutation found in patients with ARVC5, a severe subtype of arrhythmogenic right ventricular cardiomyopathy (ARVC). Characterizing
Turk J Pediatr. 2025 Oct 6;67(5):748-754. doi: 10.24953/turkjpediatr.2025.4906.ABSTRACTBACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal, genetically transmitted cardiomyopathy that can cause unpredictable malignant life-threatening arrhythmias. Arrhythmias that may be he
Biomolecules. 2025 Nov 6;15(11):1565. doi: 10.3390/biom15111565.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a cardiac disorder manifesting through electrical and contractile dysfunction of the ventricles, characterized by fibro-fatty substitution of the myocardium. Cardiac mesenchymal stromal cel
Biomolecules. 2025 Oct 25;15(11):1512. doi: 10.3390/biom15111512.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a genetic cardiac disease characterized by a progressive loss of cardiomyocytes associated with fibrofatty myocardial replacement, resulting in a heightened risk of ventricular arrhythmias
Cell Mol Life Sci. 2025 Nov 14;82(1):400. doi: 10.1007/s00018-025-05942-z.ABSTRACTArrhythmogenic right ventricular cardiomyopathy type 5 (ARVC-5) is a fully penetrant form of ARVC caused by the missense mutation in the gene TMEM43p.S358L. Despite extensive research, the molecular basis underlying th
ESC Heart Fail. 2025 Dec;12(6):4419-4430. doi: 10.1002/ehf2.70013. Epub 2025 Nov 12.ABSTRACTAIMS: Arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease characterized by fibrofatty myocardial replacement and a predisposition to malignant ventricular arrhythmias. The underlying pathomechan
Am J Physiol Heart Circ Physiol. 2025 Dec 1;329(6):H1608-H1620. doi: 10.1152/ajpheart.00416.2025. Epub 2025 Nov 10.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is an inherited heart disease characterized by myocardial inflammation and fibrosis, ventricular dysfunction, and arrhythmias, and is a leadi
Int J Cardiol. 2026 Feb 1;444:133999. doi: 10.1016/j.ijcard.2025.133999. Epub 2025 Nov 5.ABSTRACTBACKGROUND: The classification of left ventricular cardiomyopathies is challenging due to evolving definitions and overlapping phenotypes. The European Task Force Criteria, by incorporating structural, f
Stem Cell Res Ther. 2025 Nov 4;16(1):609. doi: 10.1186/s13287-025-04755-y.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a genetically inherited desmosome heart disease leading to life-threatening arrhythmias and sudden cardiac death. Currently, ACM treatment paradigms are merely symptom
Commun Biol. 2025 Oct 27;8(1):1502. doi: 10.1038/s42003-025-08921-z.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is an inherited heart disease marked by progressive fattyfibro replacement of the ventricular myocardium, life-threatening arrhythmias, and sudden cardiac death. To dissect epicardial cont
JACC Clin Electrophysiol. 2025 Nov;11(11):2532-2547. doi: 10.1016/j.jacep.2025.08.026. Epub 2025 Oct 16.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a heritable cardiac condition, which may lead to fatal arrhythmias, especially during intense exercise. Long-term regular exercise is associated with
Circ Arrhythm Electrophysiol. 2025 Nov;18(11):e014075. doi: 10.1161/CIRCEP.125.014075. Epub 2025 Oct 13.ABSTRACTBACKGROUND: Radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in arrhythmogenic right ventricular cardiomyopathy is safe and reduces ventricular arrhythmia burden. Pr
JACC Case Rep. 2025 Oct 8;30(31):105301. doi: 10.1016/j.jaccas.2025.105301.ABSTRACTBACKGROUND: Right-to-left shunting through a patent foramen ovale (PFO) can cause severe hypoxemia in right ventricular (RV) failure; however, closure may worsen RV function and risk hemodynamic collapse.CASE SUMMARY:
Nat Cardiovasc Res. 2025 Nov;4(11):1466-1486. doi: 10.1038/s44161-025-00728-9. Epub 2025 Oct 6.ABSTRACTCardiac fibrosis contributes to electrical conduction disturbances, yet its specific impact on conduction remains unclear, hindering predictive insight into cardiac electrophysiology and arrhythmog
PLoS One. 2025 Sep 29;20(9):e0332876. doi: 10.1371/journal.pone.0332876. eCollection 2025.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that predisposes affected individuals, especially young patients, to malignant arrhythmias, sudden cardiac death, and heart failure.
Adv Sci (Weinh). 2025 Dec;12(45):e12058. doi: 10.1002/advs.202512058. Epub 2025 Sep 15.ABSTRACTArrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathy featured by life-threatening arrhythmias. While TMEM43 has been identified as an ARVC-associated gene, molecular li
Biomed Pharmacother. 2025 Oct;191:118549. doi: 10.1016/j.biopha.2025.118549. Epub 2025 Sep 12.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a rare genetic cardiac disease and one of the leading causes of sudden cardiac death in young individuals and athletes. Current treatments focus on preventing
Stem Cell Res. 2025 Oct;88:103830. doi: 10.1016/j.scr.2025.103830. Epub 2025 Sep 7.ABSTRACTArrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary infiltrative cardiomyopathy characterized by fibrofatty replacement of the right ventricular myocardium, which may extend to the left vent
Circ J. 2025 Dec 25;90(1):126-133. doi: 10.1253/circj.CJ-25-0269. Epub 2025 Aug 30.ABSTRACTBACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease with a poor prognosis and no curative therapy. It may present as arrhythmogenic sudden cardiac death and inevitably pr
J Biol Chem. 2025 Oct;301(10):110644. doi: 10.1016/j.jbc.2025.110644. Epub 2025 Aug 28.ABSTRACTArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by the replacement of myocardial tissue with adipose tissue. One of the frequently mutated proteins in
Europace. 2025 Sep 1;27(9):euaf199. doi: 10.1093/europace/euaf199.ABSTRACTAIMS: Arrhythmogenic cardiomyopathy (ACM) is a genetically-determined disease characterized by malignant arrhythmias and sudden cardiac death, particularly in young individuals. Mutations in desmosomal genes are a major cause
Open Heart. 2025 Aug 27;12(2):e003502. doi: 10.1136/openhrt-2025-003502.ABSTRACTBACKGROUND: Truncating variants in the Filamin C (FLNCtv) gene are causative of highly arrhythmogenic cardiomyopathies. Guidelines remain controversial concerning competitive and high-intensity sports for FLNCtv carriers
Europace. 2025 Aug 4;27(8):euaf136. doi: 10.1093/europace/euaf136.ABSTRACTAIMS: The task force criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly sensitive but lack specificity. Atypical RV involvement (aRVi) may indicate different underlying aetiologies and prognos
Heart Rhythm. 2025 Dec;22(12):e1286-e1299. doi: 10.1016/j.hrthm.2025.08.012. Epub 2025 Aug 12.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a hereditary and life-threatening cardiac disease that primarily affects young individuals and athletes. Given that ACM is difficult to distinguish from other
