Circ Arrhythm Electrophysiol. 2026 Jul 2:e014420. doi: 10.1161/CIRCEP.125.014420. Online ahead of print.ABSTRACTBACKGROUND: Current guidelines recommend regular screening for first-degree relatives of gene-elusive arrhythmogenic right ventricular cardiomyopathy (ARVC) patients using a similar regime
Int J Cardiol. 2026 Oct 15;461:134645. doi: 10.1016/j.ijcard.2026.134645. Epub 2026 Jun 29.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease primarily associated with life-threatening ventricular arrhythmias. Improved arrhythmic risk stratification and therapi
Am J Physiol Heart Circ Physiol. 2026 Aug 1;331(2):H440-H452. doi: 10.1152/ajpheart.00368.2026. Epub 2026 Jun 27.ABSTRACTPathogenic variants in desmoglein-2 (DSG2) are a major cause of arrhythmogenic cardiomyopathy (ACM), a disease plagued by ventricular arrhythmias, contractile dysfunction, myocard
Genes (Basel). 2026 Jun 22;17(6):725. doi: 10.3390/genes17060725.ABSTRACTArrhythmogenic cardiomyopathy (ACM/ARVC) is an inherited myocardial disease characterized by progressive fibro-fatty replacement, ventricular arrhythmias, and an increased risk of sudden cardiac death. In addition to mutations
Circ Arrhythm Electrophysiol. 2026 Jul;19(7):e014877. doi: 10.1161/CIRCEP.125.014877. Epub 2026 Jun 17.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a major cause of sudden cardiac death (SCD) in competitive athletes. We aimed to evaluate the prevalence and characteristics of ACM with t
Folia Med Cracov. 2026 Mar 31;66(1):95-102. doi: 10.24425/fmc.2026.158988.ABSTRACTArrhythmogenic right ventricular cardiomyopathy, commonly detected between the second and fifth decades of life, is caused by mutations that result in the dysfunction of the junctions between cardiomyocytes. However, i
Circ Heart Fail. 2026 Jul;19(7):e013966. doi: 10.1161/CIRCHEARTFAILURE.125.013966. Epub 2026 Jun 5.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is an inherited disease that is characterized by lethal ventricular arrhythmias stemming from myocyte dysfunction. ACM is associated with conside
ESC Heart Fail. 2026 May 5;13(3):xvag163. doi: 10.1093/eschf/xvag163.ABSTRACTAIMS: To quantify central oxygen delivery (O2D), peripheral oxygen extraction, and muscle diffusive oxygen conductance (DmO2) during upper-extremity resistance and lower-extremity aerobic exercise in patients with arrhythmo
Children (Basel). 2026 May 12;13(5):669. doi: 10.3390/children13050669.ABSTRACTBackground: Cardiac channelopathies are rare but potentially life-threatening disorders that may present with syncope or seizure-like episodes in children, often leading to misdiagnosis and delayed recognition. Other arrh
Cells. 2026 May 9;15(10):868. doi: 10.3390/cells15100868.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a genetic myocardial disorder marked by progressive cardiomyocyte loss, fibro-fatty replacement, ventricular arrhythmias, and risk of sudden cardiac death. Traditionally considered a structural an
J Am Heart Assoc. 2026 May 5;15(9):e047447. doi: 10.1161/JAHA.125.047447. Epub 2026 Apr 28.ABSTRACTBACKGROUND: Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin-2 (PKP2) deficiency only in cardiomyo
Open Heart. 2026 Mar 31;13(1):e003750. doi: 10.1136/openhrt-2025-003750.ABSTRACTBACKGROUND: Truncating variants in the titin gene (TTNtv) are associated with cardiomyopathy, mainly dilated cardiomyopathy (DCM). The clinical presentation and outcomes of arrhythmogenic phenotypes in these patients are
Medicine (Baltimore). 2026 Mar 6;105(10):e47481. doi: 10.1097/MD.0000000000047481.ABSTRACTRATIONALE: Arrhythmogenic left ventricular cardiomyopathy (ALVC) is an arrhythmogenic cardiomyopathy characterized by nonischemic left-ventricular scar, ventricular arrhythmias, and risk of sudden cardiac death
Cureus. 2026 Jan 29;18(1):e102553. doi: 10.7759/cureus.102553. eCollection 2026 Jan.ABSTRACTPediatric ischemic stroke is an uncommon but serious neurological condition with highly variable etiologies. Cerebellar infarctions are particularly rare in children and often present with nonspecific symptom
Circ Arrhythm Electrophysiol. 2026 Feb;19(2):e014265. doi: 10.1161/CIRCEP.125.014265. Epub 2026 Jan 29.ABSTRACTBACKGROUND: The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populat
Zool Res. 2026 Jan 18;47(1):139-154. doi: 10.24272/j.issn.2095-8137.2025.044.ABSTRACTArrhythmogenic cardiomyopathy (ACM) confers elevated risk of ventricular arrhythmias and sudden cardiac death, yet limitations in early lesion sampling and model development continue to hinder mechanistic and transl
BMC Med Imaging. 2026 Jan 28;26(1):102. doi: 10.1186/s12880-026-02172-y.ABSTRACTBACKGROUND: The importance of right atrial (RA) function assessment in arrhythmogenic right ventricular cardiomyopathy (ARVC) is increasingly being recognized. MR-feature tracking (MR-FT) has emerged as a novel approach
Circ Heart Fail. 2026 Apr;19(4):e013801. doi: 10.1161/CIRCHEARTFAILURE.125.013801. Epub 2026 Jan 26.ABSTRACTBACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a fatal genetic heart disease primarily caused by mutations in desmosomal genes, leading to impaired cell-cell adhesion, ventricular arrhythm
Curr Cardiol Rep. 2026 Jan 17;28(1):12. doi: 10.1007/s11886-025-02327-3.ABSTRACTPURPOSE OF REVIEW: This review article summarizes the established physiologic adaptations seen on echocardiogram in athletes and provides a focus update and perspective on changing diagnostic criteria in several patholog
Trends Cardiovasc Med. 2026 Aug;36(6):367-374. doi: 10.1016/j.tcm.2025.12.005. Epub 2025 Dec 23.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a genetically determined myocardial disease characterized by myocyte loss, fibro-fatty replacement, and electrical instability. In a subset of patients, epis
PLoS One. 2025 Dec 18;20(12):e0339129. doi: 10.1371/journal.pone.0339129. eCollection 2025.ABSTRACTThe transmembrane protein 43 (TMEM43) S358L mutation is the most common mutation found in patients with ARVC5, a severe subtype of arrhythmogenic right ventricular cardiomyopathy (ARVC). Characterizing
Vet Rec. 2026 Mar-Nov 28;198(7):e287-e292. doi: 10.1002/vetr.6014. Epub 2025 Dec 6.ABSTRACTBACKGROUND: Evidence regarding the diagnostic utility of serum anti-desmoglein-2 (DSG2) autoantibodies for arrhythmogenic right ventricular cardiomyopathy (ARVC) in boxer dogs is conflicting.METHODS: Prospecti
JACC Cardiovasc Imaging. 2026 May;19(5):571-584. doi: 10.1016/j.jcmg.2025.10.019. Epub 2025 Dec 4.ABSTRACTBACKGROUND: Right ventricular outflow tract (RVOT) dilatation is a phenotypic feature of arrhythmogenic right ventricular cardiomyopathy (ARVC). The echocardiographic RVOT diameter is part of th
Turk J Pediatr. 2025 Oct 6;67(5):748-754. doi: 10.24953/turkjpediatr.2025.4906.ABSTRACTBACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal, genetically transmitted cardiomyopathy that can cause unpredictable malignant life-threatening arrhythmias. Arrhythmias that may be he
