bioRxiv [Preprint]. 2026 Jul 21:2026.07.20.739664. doi: 10.64898/2026.07.20.739664.ABSTRACTPhospholipase C-β (PLCβ) enzymes are essential effectors of G protein-coupled receptor signaling that hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane to generate the second messen
J Neurol. 2026 Jul 31;273(8):496. doi: 10.1007/s00415-026-13991-y.ABSTRACTINTRODUCTION: Classic infantile Pompe disease is the most severe phenotype within the clinical spectrum of Pompe disease and is characterized by central nervous system (CNS) involvement.METHODS: A systematic review on histopat
Medicine (Baltimore). 2026 Jul 31;105(31):e50034. doi: 10.1097/MD.0000000000050034.ABSTRACTBACKGROUND: Targeted therapy using myosin inhibitors represents a groundbreaking advancement in the management of hypertrophic cardiomyopathy (HCM). This study conducts a comprehensive bibliometric analysis to
Rev Cardiovasc Med. 2026 Jul 17;27(7):49021. doi: 10.31083/RCM49021. eCollection 2026 Jul.ABSTRACTHypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder characterized by asymmetric myocardial hypertrophy and is closely linked with myocardial fibrosis. The level and severity of myocardial fi
Rev Cardiovasc Med. 2026 Jul 23;27(7):49216. doi: 10.31083/RCM49216. eCollection 2026 Jul.ABSTRACTBACKGROUND: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic cardiovascular disease caused by mutations in genes encoding sarcomeric proteins. Positron emission tomography (PET) has de
Catheter Cardiovasc Interv. 2026 Jul 30. doi: 10.1002/ccd.70791. Online ahead of print.ABSTRACTBACKGROUND: Hypertrophic cardiomyopathy is associated with alterations in coronary microvascular function which have variable pathophysiologic mechanisms, and variable reversibility acutely and chronically
Adv Clin Exp Med. 2026 Jul;35(7):1199-1213. doi: 10.17219/acem/211410.ABSTRACTBACKGROUND: Cardiac hypertrophy refers to the compensatory response of the heart to various physiological or pathological stimuli in order to maintain its function. Let-7e-5p has been reported to be upregulated in patients
Artif Organs. 2026 Jul 30. doi: 10.1111/aor.70207. Online ahead of print.ABSTRACTBACKGROUND: Conventional mechanical circulatory support offers limited options for patients with small or restrictive left ventricles. Left atrial inflow (LA-Ao) ventricular assist device (VAD) configuration represents
J Cardiol. 2026 Jul 30:S0914-5087(26)00156-5. doi: 10.1016/j.jjcc.2026.07.017. Online ahead of print.ABSTRACTAim The dilated phase of hypertrophic cardiomyopathy (D-HCM) is associated with poor clinical outcomes. Cardiac resynchronization therapy (CRT) is an established treatment for heart failure;
J Cardiol. 2026 Jul 30:S0914-5087(26)00153-X. doi: 10.1016/j.jjcc.2026.07.014. Online ahead of print.ABSTRACTIn this nationwide survey, we investigated the use of echocardiographic stress and provocation maneuvers for hypertrophic obstructive cardiomyopathy across Japan. Among 205 echocardiography l
Med. 2026 Jul 30:101229. doi: 10.1016/j.medj.2026.101229. Online ahead of print.ABSTRACTThe emergence of gene-based therapies for hypertrophic cardiomyopathy (HCM) represents a pivotal inflection point in cardiovascular medicine, but their successful translation will depend on coordinated advances b
No abstractCardiology. 2026 Jul 30:1-4. doi: 10.1159/000551566. Online ahead of print.NO ABSTRACTPMID:42531181 | DOI:10.1159/000551566
JACC Case Rep. 2026 Jul 29;31(30):108605. doi: 10.1016/j.jaccas.2026.108605.ABSTRACTBACKGROUND: ST-segment elevation on electrocardiography is classically associated with acute transmural myocardial ischemia due to coronary artery occlusion and is central to the diagnosis of ST-segment elevation myo
JACC Case Rep. 2026 Jul 29;31(30):108232. doi: 10.1016/j.jaccas.2026.108232.ABSTRACTBACKGROUND: PRKAG2 cardiomyopathy is a genetic cardiomyopathy that phenotypically resembles hypertrophic cardiomyopathy (HCM) and results from myocardial glycogen accumulation. In addition to left ventricular hypertr
Cureus. 2026 Jun 29;18(6):e111722. doi: 10.7759/cureus.111722. eCollection 2026 Jun.ABSTRACTChest pain with apical hypertrophic cardiomyopathy (HCM) warrants concern for acute coronary syndrome (ACS). When obstructive coronary disease is excluded, myocardial bridging should remain an important consi
Clin Case Rep. 2026 Jul 28;14(8):e73051. doi: 10.1002/ccr3.73051. eCollection 2026 Aug.ABSTRACTDesmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies,
No abstractAm J Cardiol. 2026 Jul 29:S0002-9149(26)00482-0. doi: 10.1016/j.amjcard.2026.07.025. Online ahead of print.NO ABSTRACTPMID:42526673 | DOI:10.1016/j.amjcard.2026.07.025
Med. 2026 Jul 29:101230. doi: 10.1016/j.medj.2026.101230. Online ahead of print.ABSTRACTHypertrophic cardiomyopathy (HCM) is a prototypical inherited cardiomyopathy with well-defined sarcomeric genetic underpinnings that make it an attractive target for molecular therapy. We review recent advances i
J Am Coll Cardiol. 2026 Jul 29:S0735-1097(26)06770-7. doi: 10.1016/j.jacc.2026.06.004. Online ahead of print.ABSTRACTHypertrophic cardiomyopathy (HCM) in pregnancy presents unique hemodynamic and arrhythmic challenges despite generally low maternal mortality. This JACC State-of-the-Art Review synthe
Acta Cardiol Sin. 2026 Jul;42(4):544-550. doi: 10.6515/ACS.202607_42(4).20251124D.ABSTRACTBACKGROUND: Hypertrophic obstructive cardiomyopathy generally responds well to medical therapy. However, about 5% of patients require invasive procedures. There is no clear consensus on the invasive treatment f
J Mol Cell Cardiol. 2026 Jul 28:S0022-2828(26)00117-3. doi: 10.1016/j.yjmcc.2026.07.013. Online ahead of print.ABSTRACTCardiac myosin binding protein-C (cMyBP-C) is a key regulator of sarcomere structure and contractile function that modulates actomyosin interactions to control the speed and strengt
Front Physiol. 2026 Jul 6;17:1904886. doi: 10.3389/fphys.2026.1904886. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fphys.2026.1740128.].PMID:42519537 | PMC:PMC13383031 | DOI:10.3389/fphys.2026.1904886
iScience. 2026 Jul 14;29(8):116734. doi: 10.1016/j.isci.2026.116734. eCollection 2026 Aug 21.ABSTRACTMyocardial fibrosis (MF) is a pathophysiological process characterized by the excessive deposition of collagen fibers in the myocardium. Numerous studies are now dedicated to clarifying the genetic,
Echocardiography. 2026 Aug;43(8):e70567. doi: 10.1111/echo.70567.ABSTRACTINTRODUCTION: Septal myectomy treats hypertrophic obstructive cardiomyopathy (HOCM), but its effect on myocardial deformation across cardiac chambers is incompletely defined. We evaluated chamber-specific strain remodeling 1 ye
