Naunyn Schmiedebergs Arch Pharmacol. 2026 Sep 21. doi: 10.1007/s00210-026-05924-3. Online ahead of print.ABSTRACTAficamten is an approved drug to treat hypertrophic cardiomyopathy. Aficamten desensitizes bovine myofilaments against calcium cations. In isolated animal cardiac preparations, aficamten
Orv Hetil. 2026 Sep 20;167(38):1495-1506. doi: 10.1556/650.2026.33616. Print 2026 Sep 20.ABSTRACTHypertrophic cardiomyopathy is the most common structural myocardial disease. Based on the literature, its estimated prevalence in the adult population is 1 : 500. It is distinguished by an exceptionally
Rev Esp Cardiol (Engl Ed). 2026 Sep 19:S1885-5857(26)00210-0. doi: 10.1016/j.rec.2026.08.009. Online ahead of print.ABSTRACTINTRODUCTION AND OBJECTIVES: MYBPC3 is the most frequently mutated gene in hypertrophic cardiomyopathy (HCM). This study presents the clinical phenotype of a founder variant in
AJP Rep. 2026 Sep 18;16(3):e195-e199. doi: 10.1055/a-2946-5351. eCollection 2026 Jul.ABSTRACTObjective The objective of this study is to describe the prenatal sonographic and neonatal features of two siblings with lethal transaldolase deficiency and highlight its phenotypic overlap with gestational
Methodist Debakey Cardiovasc J. 2026 Sep 15;22(4):51-67. doi: 10.14797/mdcvj.1900. eCollection 2026.ABSTRACTHypertrophic cardiomyopathy (HCM) is a primary disease of cardiac myocytes caused by mutations in genes encoding sarcomere proteins. The ensuing phenotype, however, is multicellular, induced b
No abstractMethodist Debakey Cardiovasc J. 2026 Sep 15;22(4):1-3. doi: 10.14797/mdcvj.1923. eCollection 2026.NO ABSTRACTPMID:42761921 | PMC:PMC13588202 | DOI:10.14797/mdcvj.1923
Health Sci Rep. 2026 Sep 17;9(9):e72265. doi: 10.1002/hsr2.72265. eCollection 2026 Sep.ABSTRACTBACKGROUND AND AIMS: Systolic anterior motion (SAM) represents the displacement of the anterior mitral leaflet during ventricular systole toward the interventricular septum, causing an obstruction of the o
Eur J Pediatr. 2026 Sep 19;185(10):765. doi: 10.1007/s00431-026-07417-0.ABSTRACTWe aimed to assess the prevalence and spectrum of cardiac abnormalities and their associations with demographic and clinical parameters in a pediatric neurofibromatosis type 1 (NF1) cohort. One hundred fourteen NF1 cases
No abstractJACC Heart Fail. 2026 Sep 8:103357. doi: 10.1016/j.jchf.2026.103357. Online ahead of print.NO ABSTRACTPMID:42758063 | DOI:10.1016/j.jchf.2026.103357
JACC Heart Fail. 2026 Sep 17:103355. doi: 10.1016/j.jchf.2026.103355. Online ahead of print.ABSTRACTBACKGROUND: Genotype-phenotype correlations in pediatric hypertrophic cardiomyopathy (HCM) are not well established. Determining whether specific genes or variants correlate with disease severity may
No abstractCirc Res. 2026 Sep 18. doi: 10.1161/CIRCRESAHA.126.329377. Online ahead of print.NO ABSTRACTPMID:42755710 | DOI:10.1161/CIRCRESAHA.126.329377
Korean J Intern Med. 2026 Sep;41(5):884-893. doi: 10.3904/kjim.2026.065. Epub 2026 Sep 1.ABSTRACTBACKGROUND/AIMS: This study aimed to evaluate the prognostic value of artificial intelligence (AI)-based late gadolinium enhancement (LGE) quantification using cardiovascular magnetic resonance (CMR) in
Am J Med Genet A. 2026 Sep 17. doi: 10.1002/ajmg.a.70299. Online ahead of print.ABSTRACTMTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon-anticodon interactions to ensure accurate and efficient mitochondrial
Adv Biol (Weinh). 2026 Sep;10(9):e70147. doi: 10.1002/adbi.70147.ABSTRACTComorbidities, the concurrent presence of two or more medical conditions, present significant challenges for diagnosis and treatment. Skeletal muscle sarcopenia and hypertrophic cardiomyopathy (HCM) are two distinct yet interre
No abstractNat Rev Cardiol. 2026 Sep 16. doi: 10.1038/s41569-026-01353-0. Online ahead of print.NO ABSTRACTPMID:42749754 | DOI:10.1038/s41569-026-01353-0
J Genet Eng Biotechnol. 2026 Sep;24(3):100753. doi: 10.1016/j.jgeb.2026.100753. Epub 2026 Jun 29.ABSTRACTHypertrophic cardiomyopathy (HCM) is a common genetic heart disorder that can lead to heart failure or sudden death. Family-based identification of rare sarcomeric variants can support molecular
Europace. 2026 Sep 2;28(9):euag034. doi: 10.1093/europace/euag034.ABSTRACTAIMS: Non-sustained ventricular tachycardia (NSVT) is a well-established risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). However, its characteristics have been overlooked. This study evaluates
No abstractEuropace. 2026 Sep 2;28(9):euag246. doi: 10.1093/europace/euag246.NO ABSTRACTPMID:42749292 | PMC:PMC13581394 | DOI:10.1093/europace/euag246
Heart Rhythm. 2026 Sep 16:S1547-5271(26)02771-2. doi: 10.1016/j.hrthm.2026.09.006. Online ahead of print.ABSTRACTBACKGROUND: High-intensity ultrasound (HIU) ablation can produce deep myocardial lesions but has been limited by the directional, side-facing transducer orientation, yielding inconsistent
Ann Thorac Surg. 2026 Sep 16:S0003-4975(26)00919-7. doi: 10.1016/j.athoracsur.2026.09.010. Online ahead of print.ABSTRACTBACKGROUND: Surgical ablation of atrial fibrillation (AF) during septal myectomy (SM) for hypertrophic obstructive cardiomyopathy has limited evaluation. We examined national outc
Echocardiography. 2026 Sep;43(9):e70624. doi: 10.1111/echo.70624.ABSTRACTBACKGROUND: Atrial fibrillation (AF) is a common complication of hypertrophic cardiomyopathy (HCM). Whether left atrial volume index (LAVI) or resting left ventricular outflow tract (LVOT) gradient better identifies patients wh
Sci Transl Med. 2026 Sep 16;18(867):eaea2747. doi: 10.1126/scitranslmed.aea2747. Epub 2026 Sep 16.ABSTRACTHypertrophic cardiomyopathy (HCM) is marked by asymmetric cardiac wall thickening, hypercontractility, diastolic dysfunction, and fibrosis. Pathogenic sarcomere gene variants cause HCM, but comp
Am J Case Rep. 2026 Sep 16;27:e953661. doi: 10.12659/AJCR.953661.ABSTRACTBACKGROUND Advanced atrial remodeling, often associated with atrial fibrosis, may be accompanied by severe atrial electrical dysfunction and a range of electrocardiographic and arrhythmic manifestations. Data on the clinical fe
Cardiol Res Pract. 2026 Sep 15;2026:6363745. doi: 10.1155/crp/6363745. eCollection 2026.ABSTRACTBACKGROUND: Restrictive cardiomyopathy (RCM) is a rare, severe cardiac disease with a heterogeneous genetic basis. Both genetic and nongenetic factors contribute to RCM pathogenesis. Identifying the under
