Medicina (Kaunas). 2026 Apr 27;62(5):829. doi: 10.3390/medicina62050829.ABSTRACTCongenital Long QT Syndrome (LQTS) is a hereditary cardiac channelopathy defined by delayed ventricular repolarization and an elevated risk of life-threatening ventricular arrhythmias. Recent echocardiographic studies us
Children (Basel). 2026 May 12;13(5):669. doi: 10.3390/children13050669.ABSTRACTBackground: Cardiac channelopathies are rare but potentially life-threatening disorders that may present with syncope or seizure-like episodes in children, often leading to misdiagnosis and delayed recognition. Other arrh
Children (Basel). 2026 May 8;13(5):659. doi: 10.3390/children13050659.ABSTRACTBACKGROUND: Channelopathies represent a heterogeneous group of rare inherited cardiac diseases associated with life-threatening arrhythmias. Our knowledge of their epidemiology in childhood is limited. The aim of this stud
Cells. 2026 May 14;15(10):902. doi: 10.3390/cells15100902.ABSTRACTHistone deacetylase (HDAC) inhibitors are approved for cancer treatment and are being investigated for a wide range of other diseases. Despite their therapeutic promise, clinical studies have reported cardiac side effects, particularl
Heart Rhythm O2. 2026 Feb 26;7(5):938-946. doi: 10.1016/j.hroo.2026.02.017. eCollection 2026 May.ABSTRACTBACKGROUND: Fetal bradycardia has been reported in neonates with congenital long QT syndrome, but it remains unknown whether there is a general association between fetal heart rate (FHR) and the
No abstractHeartRhythm Case Rep. 2026 Feb 14;12(5):541-544. doi: 10.1016/j.hrcr.2026.02.006. eCollection 2026 May.NO ABSTRACTPMID:42181126 | PMC:PMC13198277 | DOI:10.1016/j.hrcr.2026.02.006
Bioact Mater. 2026 May 8;64:309-323. doi: 10.1016/j.bioactmat.2026.04.032. eCollection 2026 Oct.ABSTRACTCongenital long QT syndrome (LQTS) predisposes patients to malignant ventricular tachycardias, yet existing in vitro models do not fully capture the clinical arrhythmic phenotypes that determine p
Front Endocrinol (Lausanne). 2026 Apr 30;17:1828837. doi: 10.3389/fendo.2026.1828837. eCollection 2026.ABSTRACTPURPOSE: Prolonged QT intervals are clinically relevant in patients with type 2 diabetes mellitus (T2DM). However, accurately detecting the Q and T points in electrocardiogram (ECG) signals
JACC Clin Electrophysiol. 2026 May 5:S2405-500X(26)00318-X. doi: 10.1016/j.jacep.2026.03.033. Online ahead of print.ABSTRACTBACKGROUND: The diagnostic implications of a positive epinephrine challenge for long QT syndrome (LQTS) or catecholaminergic polymorphic ventricular tachycardia (CPVT) are not
Long QT Syndrome Type 2 (LQT2) is a cardiac disorder caused by Loss of Function (LOF) mutations in the KCNH2 gene that encodes the K^(+) channel hERG (K(v)11.1). Mistrafficking of hERG LOF variants is the dominant cause of LQT2. We recently characterized greatly attenuated cell surface trafficking i
Front Cardiovasc Med. 2026 Apr 29;13:1778685. doi: 10.3389/fcvm.2026.1778685. eCollection 2026.ABSTRACTThis study presents two cases of congenital long QT syndrome caused by KCNH2 gene mutations. It highlights the critical role of genetic testing in its diagnosis and underscores the importance of ea
EBioMedicine. 2026 May 13:106266. doi: 10.1016/j.ebiom.2026.106266. Online ahead of print.ABSTRACTBACKGROUND: Sudden cardiac death (SCD) is a major cause of premature and potentially avoidable mortality. Determining whether a SCD was caused by an inherited cardiac condition (ICC) enables identificat
J Gen Physiol. 2026 Jul 6;158(4):e202613981. doi: 10.1085/jgp.202613981. Epub 2026 May 13.ABSTRACTCalmodulin (CaM) serves as one of the key cellular Ca2+ sensors with >300 targets and a highly conserved structure since its appearance in early eukaryogenesis. Three distinct CaM genes (CALM1, CALM2, a
Front Cardiovasc Med. 2026 Apr 23;13:1736409. doi: 10.3389/fcvm.2026.1736409. eCollection 2026.ABSTRACTINTRODUCTION: Congenital long-QT syndrome type 1 (LQT1), one of the major LQTS subtypes caused by pathogenic variants in the KCNQ1 gene, exhibits marked phenotypic variability, including incomplete
Eur J Clin Pharmacol. 2026 May 9;82(6):148. doi: 10.1007/s00228-026-04076-w.ABSTRACTOBJECTIVE: To estimate the short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval (QTc) by emulating a published randomized controlled trial (RCT) using electronic health record (EHR) data
J Adv Res. 2026 May 3:S2090-1232(26)00386-3. doi: 10.1016/j.jare.2026.05.012. Online ahead of print.ABSTRACTINTRODUCTION: As regulatory agencies such as the FDA move toward phasing out animal testing in preclinical studies, there is a growing demand for human-relevant, cell-based models for cardiac
Clin Transl Sci. 2026 May;19(5):e70577. doi: 10.1111/cts.70577.ABSTRACTProlongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature-based synthesis and may lag
Int J Mol Sci. 2026 Apr 21;27(8):3701. doi: 10.3390/ijms27083701.ABSTRACTThe hERG potassium channel is critical for cardiac ventricular repolarization and a core target in pre-clinical drug safety screening. A robust, stable cell line with uniform, high hERG expression is essential for high-throughp
Auton Neurosci. 2026 Jun;265:103427. doi: 10.1016/j.autneu.2026.103427. Epub 2026 May 1.ABSTRACTINTRODUCTION: Congenital Long QT Syndromes type 1 and 2 (LQT1 and LQT2) are life-threatening conditions that arise from functional impairment of delayed rectifier potassium channels and predispose individ
Virus Res. 2026 Jun;368:199739. doi: 10.1016/j.virusres.2026.199739. Epub 2026 Apr 29.ABSTRACTA historical cohort study in southern Iran investigated the effect of lopinavir-ritonavir treatment, with or without azithromycin and/or hydroxychloroquine, on QT interval prolongation in 500 confirmed COVI
JCEM Case Rep. 2026 Apr 28;4(5):luag123. doi: 10.1210/jcemcr/luag123. eCollection 2026 May.ABSTRACTPrimary aldosteronism (PA) typically presents with hypertension and hypokalemia; however, its presentation as life-threatening ventricular arrhythmias is rare and often underrecognized. We report a cas
Sci Rep. 2026 Apr 29. doi: 10.1038/s41598-026-51114-9. Online ahead of print.ABSTRACTCongenital Long QT Syndrome types 1 and 2 (LQT1 and LQT2) are caused bymutations in the KCNQ1 and KCNH2 genes, responsible for the IKs and IKr currents, respectively. However, the penetrance of these mutations is hi
Case Rep Anesthesiol. 2026 Apr 27;2026:9787071. doi: 10.1155/cria/9787071. eCollection 2026.ABSTRACTVentricular electrical storm is a life-threatening emergency, especially in pediatric settings. The condition is largely mediated by heightened cardiac adrenergic tone and may be triggered by acquired
The long QT syndrome type 1 (LQT1) is caused by loss-of-function mutations affecting the potassium channel current I(Ks) important for repolarization adaptation at heart rate (HR) increase. We therefore compared changes in three global VR dispersion parameters following a rapid, atropine-induced HR
