Long QT syndrome type 1 (LQT1) results from KCNQ1 mutations that compromise the slow delayed rectifier potassium current (I(Ks)), delaying cardiac repolarization, prolonging the QT interval, and increasing risk of life-threatening arrhythmias. LQT1 proarrhythmic risk is most often triggered by exerc
Methodist Debakey Cardiovasc J. 2026 Sep 15;22(4):78-86. doi: 10.14797/mdcvj.1827. eCollection 2026.ABSTRACTInherited cardiac arrhythmias are a major cause of sudden cardiac death in individuals without structural heart disease. These conditions are primarily genetic, resulting from pathogenic varia
J Vasc Surg Cases Innov Tech. 2026 Aug 16;12(6):102454. doi: 10.1016/j.jvscit.2026.102454. eCollection 2026 Dec.ABSTRACTKidney and inferior vena cava abnormalities with leg thrombosis syndrome is a rare cause of extensive deep vein thrombosis (DVT) in young patients without evident provoking factors
Eur Heart J Cardiovasc Pharmacother. 2026 Sep 16:pvag077. doi: 10.1093/ehjcvp/pvag077. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Nausea and vomiting accompany pregnancy, gastroenteritis, migraine, the perioperative period, and cytotoxic chemotherapy, and antiemetics are among the most frequ
Am J Physiol Heart Circ Physiol. 2026 Sep 14. doi: 10.1152/ajpheart.00154.2026. Online ahead of print.ABSTRACTLong QT syndrome type 2 (LQT2) is caused by pathogenic variants in the hERG potassium channel, resulting in QT prolongation, polymorphic ventricular tachycardia (pVT), and sudden cardiac dea
Circ J. 2026 Sep 8. doi: 10.1253/circj.CJ-26-0111. Online ahead of print.ABSTRACTBACKGROUND: Syncope is common in patients with congenital long QT syndrome (LQTS). However, not all episodes of syncope or loss of consciousness are caused by torsades de pointes (TdP); some are attributable to bradycar
Cardiovasc Toxicol. 2026 Sep 6;26(10):103. doi: 10.1007/s12012-026-10174-z.ABSTRACTThe concomitant use of ceftriaxone and proton pump inhibitors (PPIs) is common in hospital practice. However, it is unclear whether individual PPIs differ in their effects on QT interval prolongation, ventricular arrh
Int J Mol Med. 2026 Nov;58(5):304. doi: 10.3892/ijmm.2026.5975. Epub 2026 Sep 4.ABSTRACTFollowing the publication of the above paper, it has been drawn to the Editor's attention by an interested reader that, regarding the Hoechst‑stained images shown in Fig. 4 on p. 1258, the 'WT‑hERG+L539fs/47‑hERG
Front Pharmacol. 2026 Aug 20;17:1904560. doi: 10.3389/fphar.2026.1904560. eCollection 2026.ABSTRACTINTRODUCTION: Long QT syndrome (LQTS) is a major substrate for malignant ventricular arrhythmias, yet population-level evidence on its clinical, pharmacological and metabolic correlates in Asian adults
Clin Case Rep. 2026 Sep 2;14(9):e73336. doi: 10.1002/ccr3.73336. eCollection 2026 Sep.ABSTRACTRisk stratification in congenital long QT syndrome (LQTS) continues to rely heavily on genotype and QTc duration, despite their limited ability to identify individuals at highest arrhythmic risk. The electr
JACC Case Rep. 2026 Sep 2:110193. doi: 10.1016/j.jaccas.2026.110193. Online ahead of print.ABSTRACTBACKGROUND: Acquired long QT syndrome and torsades de pointes (TdP) can be triggered by dietary supplements, which do not go through strict safety testing.CASE SUMMARY: A 61-year-old man had syncope an
Korean Circ J. 2026 Jul 8. doi: 10.4070/kcj.2025.0506. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: Most studies on long QT syndrome (LQTS) have been conducted in Western populations, with limited data from Asian countries. We aimed to investigate the clinical characteristics, outcomes,
Front Med (Lausanne). 2026 Aug 12;13:1954043. doi: 10.3389/fmed.2026.1954043. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fmed.2026.1857566.].PMID:42656762 | PMC:PMC13507902 | DOI:10.3389/fmed.2026.1954043
Genes (Basel). 2026 Jul 29;17(8):885. doi: 10.3390/genes17080885.ABSTRACTLong QT Syndrome type 2 (LQT2) and Brugada syndrome are inherited cardiac channelopathies that predispose affected individuals to ventricular arrhythmias and sudden cardiac death. We report the case of a 15-year-old male carryi
Eur Heart J. 2026 Aug 26:ehag610. doi: 10.1093/eurheartj/ehag610. Online ahead of print.ABSTRACTInherited arrhythmia syndromes (IAS)-including long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and Brugada syndrome (BrS)-are important causes of sudden cardiac deat
J Am Heart Assoc. 2026 Sep;15(17):e050282. doi: 10.1161/JAHA.126.050282. Epub 2026 Aug 20.ABSTRACTCardiac channelopathies are inherited arrhythmias that can lead to sudden cardiac death. Despite Africa's extensive genomic diversity, African and African-descent populations remain underrepresented in
Cureus. 2026 Jul 20;18(7):e113017. doi: 10.7759/cureus.113017. eCollection 2026 Jul.ABSTRACTIntroduction Cardiomyopathies (CMs), as well as primary electrical disorders, i.e., inherited arrhythmia syndromes (IAS), including long-QT syndrome, catecholaminergic polymorphic ventricular tachycardia, and
Front Pediatr. 2026 Jul 31;14:1932796. doi: 10.3389/fped.2026.1932796. eCollection 2026.ABSTRACTBACKGROUND: The interpretation of pediatric electrocardiograms (ECGs) and management of childhood arrhythmias represent specialized clinical disciplines complicated by age-dependent physiological evolutio
BMJ Open. 2026 Aug 14;16(8):e118322. doi: 10.1136/bmjopen-2026-118322.ABSTRACTINTRODUCTION: Methadone is a long-acting opioid used to treat opioid use disorder, cancer pain and provide perioperative analgesia. Methadone administration has been associated with QTc interval prolongation and consequent
Front Cardiovasc Med. 2026 Jul 30;13:1868969. doi: 10.3389/fcvm.2026.1868969. eCollection 2026.ABSTRACTCritical limb ischemia (CLI) secondary to femoral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a recognized and morbid complication, with an incidence reaching 25.4% when prophyla
Eur J Pharmacol. 2026 Sep 10;1032:179216. doi: 10.1016/j.ejphar.2026.179216. Epub 2026 Aug 12.ABSTRACTHigh cholesterol is a key cardiovascular risk factor that can modulate cardiac electrophysiology and promote acquired long QT syndrome (acLQTS)-related cardiotoxicity, a potentially life-threatening
Circ Rep. 2026 Jun 23;8(8):1220-1227. doi: 10.1253/circrep.CR-26-0138. eCollection 2026 Aug 10.ABSTRACTBACKGROUND: The corrected QT interval (QTc) is essential for long QT syndrome (LQTS) screening. QTc values change with growth, and sex differences emerge at puberty. However, few longitudinal studi
Br J Sports Med. 2026 Aug 10:bjsports-2025-111459. doi: 10.1136/bjsports-2025-111459. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the results of cardiac screening, prevalence of cardiac diseases and subsequent health outcomes among elite female football players in the UK.METHODS: Between
Clin Transl Sci. 2026 Aug;19(8):e70698. doi: 10.1111/cts.70698.ABSTRACTDrug-induced QTc prolongation (diQTP) is a major risk factor for torsades de pointes and sudden cardiac death. This study evaluated whether carriers of the G allele of the NOS1AP rs10494366 T > G variant have greater risk for diQ
