Transl Pediatr. 2026 Feb 28;15(2):60. doi: 10.21037/tp-2025-630. Epub 2026 Feb 12.ABSTRACTBACKGROUND: Familial glucocorticoid deficiency type 4 (GCCD4), caused by nicotinamide nucleotide transhydrogenase (NNT) gene mutations, represents a rare multisystem disorder with poorly characterized cardiac m
J Arrhythm. 2026 Mar 8;42(2):e70308. doi: 10.1002/joa3.70308. eCollection 2026 Apr.ABSTRACTAIMS: Implantable cardioverter-defibrillator (ICD) therapy in children, particularly for primary prevention, remains under investigation, with limited data from less affluent European countries. With increasin
BMJ Paediatr Open. 2026 Mar 9;10(1):e004403. doi: 10.1136/bmjpo-2025-004403.ABSTRACTOBJECTIVE: To describe the development and utilisation of a paediatric inherited arrhythmia clinic (IAC) from 2014 to 2024, including service developments following the introduction of cardiac genetic coordinators (C
Clin Pharmacol Drug Dev. 2026 Mar;15(3):e70039. doi: 10.1002/cpdd.70039.ABSTRACTCIN-102 is a deuterated form of domperidone in development for the treatment of acute, recurrent gastroparesis. This thorough QT study assessed the effects of CIN-102 on cardiac repolarization in 62 healthy volunteers. I
PLoS One. 2026 Mar 6;21(3):e0340092. doi: 10.1371/journal.pone.0340092. eCollection 2026.ABSTRACTBACKGROUND: Mirtazapine is widely used in the treatment of major depressive disorder (MDD), yet its real-world safety profile remains insufficiently evaluated.METHODS: This study analyzed adverse event (
Health Sci Rep. 2026 Mar 2;9(3):e71977. doi: 10.1002/hsr2.71977. eCollection 2026 Mar.ABSTRACTBACKGROUND AND AIMS: The KCNK17 gene encodes k2p17.1 channels (TASK-4 or TALK-2) with dominant expressions in the atria and the Purkinje fibers. Emerging studies have suggested possible associations between
Clin Transl Sci. 2026 Mar;19(3):e70518. doi: 10.1111/cts.70518.ABSTRACTFenebrutinib is a Bruton's tyrosine kinase inhibitor under investigation for the treatment of multiple sclerosis. The goal of this study was to investigate the effect of fenebrutinib on cardiac repolarization (QT interval) as wel
Eur J Pediatr. 2026 Mar 4;185(3):160. doi: 10.1007/s00431-026-06768-y.ABSTRACTPhysicians tasked with caring for children with inherited cardiac conditions (ICCs) face complex decisions regarding safe participation in physical activity and competitive sport. Historically, concerns over sudden cardiac
Annu Model Simul Conf ANNSIM. 2025 May;2025:11118706. Epub 2025 Aug 19.ABSTRACTLong QT Syndrome type 3 (LQT3) arises from mutations in SCNA5 gene encoding the Nav1.5 sodium channel. We studied two novel mutations (G1481V and Q1491H) found in infants who suffered sudden cardiac death. Using computati
Front Cardiovasc Med. 2026 Feb 12;13:1680300. doi: 10.3389/fcvm.2026.1680300. eCollection 2026.ABSTRACTLong QT syndrome (LQTS) is a hereditary cardiac channelopathy associated with delayed ventricular repolarization and increased risk of life-threatening arrhythmias and sudden cardiac death. We repo
Proper regulation of the cardiac L-type calcium channel (Ca(V)1.2) involves calcium-dependent inactivation (CDI) of the channel. CDI is mediated by the calcium-sensing protein calmodulin (CaM), which interacts with the IQ domain of Ca(V)1.2. CaM mutations have been implicated in dangerous cardiac ar
Front Biosci (Landmark Ed). 2026 Feb 12;31(2):49097. doi: 10.31083/FBL49097.ABSTRACTBACKGROUND: Long-QT syndrome type 2 (LQTS2), which is associated with life-threatening cardiac arrhythmias, is caused by pathogenic heterozygous loss-of-function mutations in the KCNH2 gene. This gene encodes the por
bioRxiv [Preprint]. 2026 Feb 20:2026.02.20.707017. doi: 10.64898/2026.02.20.707017.ABSTRACTThe human ether-à-go-go related gene ( hERG ) encodes a potassium channel essential for cardiac repolarization and neuronal excitability. In the heart, heteromeric assemblies of hERG1a and hERG1b subunits prod
Sci Rep. 2026 Feb 26;16(1):7744. doi: 10.1038/s41598-026-41843-2.ABSTRACTWhile primarily a disease of older adults due to coronary artery disease, sudden cardiac arrest (SCA) also affects younger individuals, particularly those with genetic predispositions or congenital heart defects. This study aim
J Cardiovasc Dev Dis. 2026 Jan 27;13(2):65. doi: 10.3390/jcdd13020065.ABSTRACTNeonatal arrhythmias, though relatively uncommon, can range from benign self-limiting conditions to life-threatening disorders requiring intensive management. Data on their clinical spectrum, management, and outcomes remai
JACC Case Rep. 2026 Feb 24:107050. doi: 10.1016/j.jaccas.2026.107050. Online ahead of print.ABSTRACTBACKGROUND: Patients with congenital long QT syndrome (LQTS) are at increased risk for sudden cardiac death.CASE SUMMARY: We present the case of a young woman with a history of syncopal episodes trigg
No abstractHeartRhythm Case Rep. 2025 Nov 1;12(1):58-61. doi: 10.1016/j.hrcr.2025.10.039. eCollection 2026 Jan.NO ABSTRACTPMID:41732457 | PMC:PMC12925696 | DOI:10.1016/j.hrcr.2025.10.039
bioRxiv [Preprint]. 2026 Feb 13:2026.02.11.705466. doi: 10.64898/2026.02.11.705466.ABSTRACTHuman iPSC-derived engineered heart tissues (EHTs) and cardiac organoids are increasingly used to model cardiac physiology and drug responses, yet it remains unclear whether they can reproduce tissue-scale mec
No abstractSci Rep. 2026 Feb 18. doi: 10.1038/s41598-026-40578-4. Online ahead of print.NO ABSTRACTPMID:41708799 | DOI:10.1038/s41598-026-40578-4
Cureus. 2026 Jan 16;18(1):e101667. doi: 10.7759/cureus.101667. eCollection 2026 Jan.ABSTRACTGitelman syndrome (GS) is an autosomal recessive salt-wasting tubulopathy caused by pathogenic variants in SLC12A3, characterized by renal potassium wasting, hypokalemic metabolic alkalosis, hypomagnesemia, a
No abstractSci Rep. 2026 Feb 16. doi: 10.1038/s41598-026-37707-4. Online ahead of print.NO ABSTRACTPMID:41699000 | DOI:10.1038/s41598-026-37707-4
Eur Heart J Case Rep. 2026 Jan 31;10(2):ytag064. doi: 10.1093/ehjcr/ytag064. eCollection 2026 Feb.ABSTRACTBACKGROUND: Andersen-Tawil syndrome is characterized by a symptom triad of cardiac electrical abnormalities, periodic muscular paralysis, and distinct dysmorphic manifestations. A history of une
No abstractHeart Rhythm O2. 2025 Nov 13;7(1):193-195. doi: 10.1016/j.hroo.2025.11.005. eCollection 2026 Jan.NO ABSTRACTPMID:41695503 | PMC:PMC12902294 | DOI:10.1016/j.hroo.2025.11.005
Stem Cell Res. 2026 Feb 3;92:103921. doi: 10.1016/j.scr.2026.103921. Online ahead of print.ABSTRACTKCNQ1 functions as a slow rectifying potassium channel during the repolarization of the cardiac action potential, with mutations causing long-QT syndrome 1 and arrhythmias. A genetic link between KCNQ1
