PLoS One. 2026 Jul 29;21(7):e0354816. doi: 10.1371/journal.pone.0354816. eCollection 2026.ABSTRACTBACKGROUND: Isavuconazole (ISCZ) is an azole antifungal with a low risk of QTc prolongation and no requirement for renal dose adjustment. However, real-world data in Asian patients remain limited.METHOD
The calcium (Ca^(2+)) sensor calmodulin (CaM) genes CALM1, CALM2, and CALM3 were recently included in the American College Medical Genetics and Genomics (ACMG) secondary findings (SF) list, given their significance in causing long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tach
Genes (Basel). 2026 Jul 17;17(7):818. doi: 10.3390/genes17070818.ABSTRACTBACKGROUND: Variant interpretation in clinical genomics requires integration of population-specific allele frequencies, curated database annotations, and phenotype evidence. However, variants annotated as pathogenic or likely p
J Cardiovasc Dev Dis. 2026 Jul 15;13(7):332. doi: 10.3390/jcdd13070332.ABSTRACTBACKGROUND/OBJECTIVES: Children with congenital long QT syndrome (cLQTS) are at extremely high risk of torsades de pointes (TdP) and sudden cardiac death (SCD). Although the implantable cardioverter-defibrillator (ICD) is
J Med Case Rep. 2026 Jul 19. doi: 10.1186/s13256-026-06397-x. Online ahead of print.ABSTRACTBACKGROUND: Ventral hernias are common abdominal wall defects, usually occurring as isolated entities related to prior surgery, trauma, or increased intra-abdominal pressure. The occurrence of multiple synchr
Eur Heart J. 2026 Jul 17:ehag513. doi: 10.1093/eurheartj/ehag513. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Congenital long QT syndrome (LQTS) is a heterogeneous disorder in which genotype and QTc duration modulate the risk of major arrhythmic events (MAEs), but contemporary paediatric outc
J Am Heart Assoc. 2026 Jul 21;15(14):e047140. doi: 10.1161/JAHA.125.047140. Epub 2026 Jul 17.ABSTRACTBACKGROUND: Women with congenital long-QT syndrome (LQTS) experience increased risk of cardiac events (CE) after the onset of adolescence, possibly due to the effect of sex hormones on the cardiac io
JACC Case Rep. 2026 Jul 15;31(28):108600. doi: 10.1016/j.jaccas.2026.108600.ABSTRACTBACKGROUND: Long QT syndrome has traditionally led to exercise restriction due to concerns for exertion-triggered arrhythmia and sudden cardiac death. Emerging data, however, support individualized participation guid
JACC Case Rep. 2026 Jul 15;31(28):108906. doi: 10.1016/j.jaccas.2026.108906.ABSTRACTBACKGROUND: The SCN5A gene encodes the alpha subunit of the cardiac sodium channel; variants are associated with inherited cardiac diseases including long QT syndrome, sick sinus syndrome, dilated cardiomyopathy, arr
Front Pharmacol. 2026 Jul 1;17:1776465. doi: 10.3389/fphar.2026.1776465. eCollection 2026.ABSTRACTINTRODUCTION: Osimertinib, a third-generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI), is central to first-line therapy for EGFR-mutant Non-Small Cell Lung Cancer (NSCLC),
BMC Med Genomics. 2026 Jul 15. doi: 10.1186/s12920-026-02428-0. Online ahead of print.ABSTRACTBACKGROUND: Long QT syndrome (LQTS) is considered a primary cardiac ion channelopathy. Several studies have shown that myocardial functional alterations may occur in patients with LQTS type 3 (LQT3). Howeve
BMC Anesthesiol. 2026 Jul 16. doi: 10.1186/s12871-026-04101-6. Online ahead of print.ABSTRACTBACKGROUND: Congenital long QT syndromes (cLQTS) are inherited cardiac channelopathies that predispose pediatric patients to ventricular arrhythmias, particularly Torsades de Pointes (TdP), during the periop
Exp Mol Pathol. 2026 Jul 15;147:105068. doi: 10.1016/j.yexmp.2026.105068. Online ahead of print.ABSTRACTSudden cardiac death (SCD) in individuals ≤35 years remains a major challenge for cardiology and forensic medicine, often affecting subjects without prior symptoms. At the same time, the consumpti
Clin Pract Cases Emerg Med. 2025 Aug;9(3):274-277. doi: 10.5811/cpcem.1573.ABSTRACTINTRODUCTION: Brugada syndrome, a cardiac channelopathy, manifests with ventricular arrhythmia. Diagnosis relies on a type 1 Brugada electrocardiogram (ECG) pattern, while type 2 and type 3 patterns may necessitate el
J Arrhythm. 2026 Jul 14;42(4):e70422. doi: 10.1002/joa3.70422. eCollection 2026 Aug.ABSTRACTBACKGROUND: Non-selective beta-blockers, such as propranolol, are highly effective in reducing arrhythmia risk in long QT Syndrome (LQTS). The study aim was to evaluate the use of beta-blockers, especially be
The voltage-gated potassium channel K(V)7.1 (KCNQ1) is essential for cardiac repolarization. Loss-of-function mutations prolong the action potential and cause long QT syndrome 1, predisposing to malignant arrhythmias. Pharmacological activators of K(V)7.1 are therefore of therapeutic interest. Among
NPJ Cardiovasc Health. 2026 Jul 10;3(1):43. doi: 10.1038/s44325-026-00145-2.ABSTRACTAccurate and continuous electrocardiogram (ECG) parameter measurement outside hospital environments is essential for real-time cardiac health monitoring and telemedicine, yet comprehensive validation of on-device com
Front Cardiovasc Med. 2026 Jun 25;13:1841777. doi: 10.3389/fcvm.2026.1841777. eCollection 2026.ABSTRACTHypertrophic cardiomyopathy (HCM) is an autosomal dominant primary myocardial disease, primarily caused by pathogenic variants in genes encoding sarcomere-associated proteins. Among these, the card
CONCLUSIONS: The KCNH2 mutation was associated with I(CaL) gating abnormalities crucially contributing to APD prolongation, which were largely corrected by E2. However, by accelerating I(CaL) recovery, E2 facilitated EADs despite APD shortening.J Mol Cell Cardiol. 2026 Aug;217:176-188. doi: 10.1016/
J Innov Card Rhythm Manag. 2026 Jun 15;17(6):6749-6752. doi: 10.19102/icrm.2026.17064. eCollection 2026 Jun.ABSTRACTThis case report describes a 57-year-old woman with a history of transient loss of consciousness, initially treated as epilepsy, who presented with recurrent torsades de pointes requir
Cureus. 2026 Jun 2;18(6):e110146. doi: 10.7759/cureus.110146. eCollection 2026 Jun.ABSTRACTGitelman syndrome is an inherited renal tubulopathy characterized by hypokalemia and hypomagnesemia, which can increase susceptibility to cardiac arrhythmias. Although ventricular arrhythmias have been reporte
Fam Pract. 2026 Jun 11;43(4):cmag048. doi: 10.1093/fampra/cmag048.ABSTRACTBACKGROUND: Tisdale risk score has been validated for predicting drug-induced QTc prolongation (QTP) in cardiac care. This study aims to determine whether it can guide prescribing and monitoring of QTc-prolonging medications i
Pediatr Discov. 2026 Apr 8;4(2):e70047. doi: 10.1002/pdi3.70047. eCollection 2026 Jun.ABSTRACTJervell and Lange-Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCN
Ann Noninvasive Electrocardiol. 2026 Jul;31(4):e70217. doi: 10.1111/anec.70217.ABSTRACTINTRODUCTION: Sex steroid hormones influence ventricular repolarization and QT interval duration. Testosterone has been associated with shorter QT intervals, whereas androgen deprivation may prolong repolarization
