Front Cardiovasc Med. 2026 Jul 22;13:1900085. doi: 10.3389/fcvm.2026.1900085. eCollection 2026.ABSTRACTInherited arrhythmia syndromes-including Brugada syndrome (BrS), long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and short QT syndrome (SQTS)-can cause malign
JACC Case Rep. 2026 Jul 29;31(30):108675. doi: 10.1016/j.jaccas.2026.108675.ABSTRACTBACKGROUND: We present a case of short QT syndrome (SQTS) initially manifesting as atrial fibrillation (AF) and degenerating to polymorphic ventricular tachycardia (PMVT), successfully managed with quinidine.CASE SUM
JACC Case Rep. 2026 Sep 2;31(35):109218. doi: 10.1016/j.jaccas.2026.109218. Epub 2026 Jul 9.ABSTRACTBACKGROUND: Short QT syndrome (SQTS) is a rare inherited channelopathy associated with malignant ventricular arrhythmias and sudden cardiac death.CASE SUMMARY: A 48-year-old man presented with syncope
Life (Basel). 2026 Jun 5;16(6):959. doi: 10.3390/life16060959.ABSTRACTShort QT syndrome (SQTS) is a rare, inherited cardiac channelopathy characterized by an abnormally shortened QT interval, accelerated ventricular repolarization, and an increased risk of atrial and ventricular tachyarrhythmias, in
Nat Commun. 2026 Jun 20;17(1):7832. doi: 10.1038/s41467-026-74259-7.ABSTRACTShort QT Syndrome type 3 (SQTS3) is an inherited disorder marked by an abnormally short QT interval on ECG and a high risk of life-threatening arrhythmias, for which effective targeted therapies are lacking. SQTS3 is caused
[Figure: see text]JACC Case Rep. 2026 Jun 17;31(24):108482. doi: 10.1016/j.jaccas.2026.108482.ABSTRACT[Figure: see text]PMID:42312754 | PMC:PMC13309700 | DOI:10.1016/j.jaccas.2026.108482
J Innov Card Rhythm Manag. 2026 May 15;17(5):6744-6747. doi: 10.19102/icrm.2026.17053. eCollection 2026 May.ABSTRACTShort QT syndrome (SQTS) is a rare inherited cardiac channelopathy disease resulting from mutations in potassium channels. It has been associated with several dysrhythmias, including v
Children (Basel). 2026 May 12;13(5):669. doi: 10.3390/children13050669.ABSTRACTBackground: Cardiac channelopathies are rare but potentially life-threatening disorders that may present with syncope or seizure-like episodes in children, often leading to misdiagnosis and delayed recognition. Other arrh
JACC Case Rep. 2026 Jun 17;31(24):108318. doi: 10.1016/j.jaccas.2026.108318. Epub 2026 May 14.ABSTRACTBACKGROUND: Short QT syndrome (SQTS) is a rare cardiac channelopathy and can cause malignant arrhythmia and sudden cardiac arrest.CASE SUMMARY: A 4-year-and-6-month-old girl presented with intermitt
J Clin Med. 2026 May 1;15(9):3461. doi: 10.3390/jcm15093461.ABSTRACTBackground: Short QT syndrome (SQTS) is a rare inherited cardiac channelopathy associated with high risk of atrial and ventricular arrhythmias and sudden cardiac death (SCD). Data on its natural history, genotype-phenotype correlati
J Mol Diagn. 2026 Jul;28(7):565-574. doi: 10.1016/j.jmoldx.2026.04.004. Epub 2026 May 4.ABSTRACTAlthough structural heart abnormalities are not typically associated with short QT syndrome (SQTS)-related sudden unexpected death, few autopsy studies have examined the underlying pathology and genetic f
No abstractHeartRhythm Case Rep. 2026 Jan 28;12(4):464-471. doi: 10.1016/j.hrcr.2026.01.015. eCollection 2026 Apr.NO ABSTRACTPMID:42028086 | PMC:PMC13100622 | DOI:10.1016/j.hrcr.2026.01.015
JCI Insight. 2026 Apr 8;11(7):e197721. doi: 10.1172/jci.insight.197721. eCollection 2026 Apr 8.ABSTRACTShort QT syndrome is a heritable arrhythmia disorder linked to sudden cardiac death. We recently identified that individuals with alternating hemiplegia of childhood (AHC), a rare neurodevelopmenta
Sci Rep. 2026 Feb 26;16(1):7744. doi: 10.1038/s41598-026-41843-2.ABSTRACTWhile primarily a disease of older adults due to coronary artery disease, sudden cardiac arrest (SCA) also affects younger individuals, particularly those with genetic predispositions or congenital heart defects. This study aim
No abstractHeartRhythm Case Rep. 2025 Oct 13;12(1):48-51. doi: 10.1016/j.hrcr.2025.10.006. eCollection 2026 Jan.NO ABSTRACTPMID:41732448 | PMC:PMC12925700 | DOI:10.1016/j.hrcr.2025.10.006
Europace. 2026 Feb 3;28(2):euag011. doi: 10.1093/europace/euag011.ABSTRACTAIMS: Electromechanical coupling and mechano-electrical feedback (MEF) are crucial for cardiac function, but their pro-arrhythmic roles in short and long QT syndromes (SQT1 and LQT2) are not fully understood. We aimed to evalu
PLoS Comput Biol. 2025 Nov 19;21(11):e1013616. doi: 10.1371/journal.pcbi.1013616. eCollection 2025 Nov.ABSTRACTPatients with abbreviated cardiac repolarization are at increased risk of cardiac arrhythmias including ventricular and atrial fibrillation (AF). In this computational simulation study, we
In cardiomyocytes, Kv7.1 associates with the regulatory subunit KCNE1 to generate the delayed rectifier potassium current I(Ks), which plays a crucial role in cardiac repolarization at elevated heart rates. Gain-of-function mutations in either of these subunits are associated with short QT syndrome,
Medicine (Baltimore). 2025 Sep 12;104(37):e44449. doi: 10.1097/MD.0000000000044449.ABSTRACTThe relationship between corrected QT (QTc) intervals and short-term clinical outcomes remains insufficiently investigated. This study examined correlations between QTc intervals and risks of arrhythmia or mor
Eur Heart J. 2026 Jan 7;47(2):199-213. doi: 10.1093/eurheartj/ehaf660.ABSTRACTBACKGROUND AND AIMS: Type 1 short QT syndrome (SQT1) is a genetic channelopathy caused by gain-of-function variants in KCNH2, resulting in shortened cardiac repolarization and QT intervals, which predispose patients to ven
Stem Cell Res. 2025 Oct;88:103815. doi: 10.1016/j.scr.2025.103815. Epub 2025 Aug 22.ABSTRACTThis study established an iPSC line, JXEYi001-A, from a 7-year-old male with a KCNJ2 mutation linked to ventricular arrhythmias (VA). KCNJ2 encodes Kir2.1, essential for cardiac repolarization; its mutations
Front Cardiovasc Med. 2025 Jul 31;12:1555512. doi: 10.3389/fcvm.2025.1555512. eCollection 2025.ABSTRACTOBJECTIVE: QT interval irregularities correlate with severe arrhythmias and sudden cardiac death. However, epidemiological data on QT intervals in Chinese adults are lacking. This study aimed to el
Eur Heart J Case Rep. 2025 Jul 24;9(8):ytaf348. doi: 10.1093/ehjcr/ytaf348. eCollection 2025 Aug.ABSTRACTBACKGROUND: A subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to a conventional transvenous implantable cardioverter defibrillator for preventing sudden cardiac deat
Indian Pacing Electrophysiol J. 2025 Aug 2:S0972-6292(25)00109-3. doi: 10.1016/j.ipej.2025.07.018. Online ahead of print.ABSTRACTAt the beginning of the last century, quinidine had been shown to be highly effective in the management of atrial fibrillation and soon after of ventricular arrhythmias. A
